Cytomorphology of notochordal and chondrocytic cells from the nucleus pulposus: a species comparison
نویسندگان
چکیده
منابع مشابه
The Comparative Cytomorphology of Nucleus Pulposus Cells
INTRODUCTION The cells of the embryonic notochord play an important role in formation of the spinal column, including the intervertebral discs (IVDs) (1). These cells become trapped inside the annulus fibrosus and reside within the nucleus pulposus at birth, but are generally lost during aging and replaced by small chondrocyte-like cells. The age at which the notochordal cells are lost varies s...
متن کاملThe Regenerative Potential of Notochordal Cells in a Nucleus Pulposus Explant
STUDY DESIGN In vitro disk explant culture. OBJECTIVE Notochordal cells (NCs) have been shown to upregulate matrix production by nucleus pulposus (NP) cells in coculture. To examine the translation of these in vitro results to a nativelike setting, the regenerative potential of NCs injected into NP tissue was assessed in this study. METHODS NP explants were cultured after injection with NCs...
متن کاملNotochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration
INTRODUCTION The relative resistance of non-chondrodystrophic (NCD) canines to degenerative disc disease (DDD) may be due to a combination of anabolic and anti-catabolic factors secreted by notochordal cells within the intervertebral disc (IVD) nucleus pulposus (NP). Factors known to induce DDD include interleukin-1 beta (IL-1ß) and/or Fas-Ligand (Fas-L). Therefore we evaluated the ability of n...
متن کاملConditioned medium derived from notochordal cell-rich nucleus pulposus tissue stimulates matrix production by canine nucleus pulposus cells and bone marrow-derived stromal cells.
OBJECTIVES Conditioned medium derived from notochordal cell-rich nucleus pulposus tissue (NCCM) was previously shown to have a stimulatory effect on bone marrow stromal cells (BMSCs) and nucleus pulposus cells (NPCs) individually, in mixed species in vitro cell models. The objective of the current study was to assess the stimulatory effect of NCCM on NPCs in a homologous canine in vitro model a...
متن کاملNotochordal cell rich nucleus pulposus tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human MSCs
pulposus phenotype in human MSCs +Purmessur, D; Godburn K; Abbott, RD: Schek RM; Iatridis JC +University of Vermont, Burlington VT Senior author [email protected] INTRODUCTION Mesenchymal stem cells (MSCs) are an attractive cell source for IVD repair, yet the means of differentiating these cells to a nucleus pulposus (NP) phenotype is not clear and an area of high priority. Notochordal cel...
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ژورنال
عنوان ژورنال: Journal of Anatomy
سال: 2004
ISSN: 0021-8782,1469-7580
DOI: 10.1111/j.0021-8782.2004.00352.x